Solid tumors account for approximately 30% of all pediatric cancers. Although chemotherapy has largely contributed to strongly improve patient outcome, multidrug resistance (MDR) remains one of the major mechanisms limiting the overall survival. The enhanced efflux rate of chemotherapeutic drugs from tumor cells through drug transporters is one of the most important mechanisms of MDR. Drug transporters play a pivotal role in preserving the balance between sensitivity and resistance of tumor cells to anti-neoplastic drugs. Their functional activities have been barely investigated in pediatric solid malignancies. Here, we provide evidence from the current literatures on drug transporters and MDR in the most common types of pediatric solid tumors, including neuroblastoma, Wilms’ tumor, rhabdomyosarcoma, retinoblastoma, medulloblastoma and hepatoblastoma.

Drug transporters and multiple drug resistance in the most common pediatric solid tumors / Fruci, D; and Cho, Wcs; Romania, P; and Nobili, V; and Locatelli, F; and Alisi, A.. - In: CURRENT DRUG METABOLISM. - ISSN 1389-2002. - 17:4(2016), pp. 308-316. [10.2174/1567205010666131212110948]

Drug transporters and multiple drug resistance in the most common pediatric solid tumors

Romania P;and Locatelli F;
2016

Abstract

Solid tumors account for approximately 30% of all pediatric cancers. Although chemotherapy has largely contributed to strongly improve patient outcome, multidrug resistance (MDR) remains one of the major mechanisms limiting the overall survival. The enhanced efflux rate of chemotherapeutic drugs from tumor cells through drug transporters is one of the most important mechanisms of MDR. Drug transporters play a pivotal role in preserving the balance between sensitivity and resistance of tumor cells to anti-neoplastic drugs. Their functional activities have been barely investigated in pediatric solid malignancies. Here, we provide evidence from the current literatures on drug transporters and MDR in the most common types of pediatric solid tumors, including neuroblastoma, Wilms’ tumor, rhabdomyosarcoma, retinoblastoma, medulloblastoma and hepatoblastoma.
2016
abc transporters; mdr1; mrp1; multidrug resistance; neoadjuvant chemotherapy; pediatric solid tumors
01 Pubblicazione su rivista::01a Articolo in rivista
Drug transporters and multiple drug resistance in the most common pediatric solid tumors / Fruci, D; and Cho, Wcs; Romania, P; and Nobili, V; and Locatelli, F; and Alisi, A.. - In: CURRENT DRUG METABOLISM. - ISSN 1389-2002. - 17:4(2016), pp. 308-316. [10.2174/1567205010666131212110948]
File allegati a questo prodotto
File Dimensione Formato  
Fruci_Drug_2016.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 528.27 kB
Formato Adobe PDF
528.27 kB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1408093
Citazioni
  • ???jsp.display-item.citation.pmc??? 15
  • Scopus 35
  • ???jsp.display-item.citation.isi??? 37
social impact